How not brushing your teeth could cause CANCER
BACTERIA that builds up in your mouth when you don’t brush your teeth could cause cancer, experts have warned.
A new study has revealed disease producing organisms (pathogens) surrounding the teeth can contribute to “highly aggressive” forms of oral cancer.
Risk factors for oral cancer include smoking, alcohol consumption and the HPV (human papilloma virus) infection.
Experts have now said that oral pathogens could explain the development of tumours in the mouth.
The experts at the University of California found that three types of pathogens enhanced tumour formation in mice.
These pathogens were inhibited by treatment with nisin.
Top tips for a healthier smile
Dental professional Dr Deepak Aulak, who is also co-founder of the Tooth Fairy App said it’s extremely important to stay on top of your dental hygiene and revealed his top tips.
- Avoid drinking and eating things that can stain: Dr Aulak said: "These can include wine, smoking and black coffee. If you are to have one of these, it is important to clean well after with a baking soda toothpaste such as Arm and Hammer."
- Brush daily: Brushing daily with an effective stain removal toothpaste can help. He added that you should use a paste which gently removes plaque.
- Floss: Dr Aulak said flossing is important and recommended using a flosser which is angled in order to get to all those hard to reach places. He added: "It is highly advisable to floss daily to help prevent cavities, gum disease as well as eliminate bad breath. Flossing helps remove bacteria and debris between the teeth, where conventional brushing may not be as effective."
He added: "Many oral health issues can be prevented through good cleaning and changes in the diet by patients themselves.
"That is why it is important for patients to be well equipped with dental knowledge of self-maintenance."
Nisin is commonly used as a food preservative.
Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers worldwide and oral squamous cell carcinoma is a subset of this and accounts for around 90 per cent of all oral malignancies.
The experts tested whether OSCC is promoted by those affecting structures surrounding and supporting teeth.
The study published in the open-access journal PLOS Pathogens by Yvonne Kapila states that the experts found three types of periodontal pathogens.
The three pathogens found were Porphyromonas gingivalis, Treponema denticola, and Fusobacterium nucleatum – which all enhanced OSCC cell migration, invasion, and tumor formation in mice.
The authors state that this is the first study that offers direct evidence that a bacteriocin inhibits oral cancer formation mediated by periodontal pathogens.
The findings also suggest that the use of nisin could be used as a broader treatment as an anticancer agent.
The authors conclude: "Since a probiotic bacteriocin peptide, nisin, rescues this pathogen-mediated carcinogenesis, these findings could advance treatment for oral cancer and establish a novel paradigm for cancer treatment focused on antimicrobial-based therapies."
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